Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care
نویسندگان
چکیده
منابع مشابه
Natural Variations in Maternal Care Are Associated with Estrogen Receptor Expression and Estrogen Sensitivity in the Medial Preoptic Area
Lactating rats exhibit stable individual differences in pup licking/grooming (LG) over the first week postpartum. Such naturally occurring variations in maternal behavior are associated with differences in estrogen-inducible oxytocin receptors in the medial preoptic area (MPOA) of the hypothalamus. We compared levels of ER and ER mRNA in the MPOA of lactating High or Low LG mothers as well as i...
متن کاملNatural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area.
Lactating rats exhibit stable individual differences in pup licking/grooming (LG) over the first week postpartum. Such naturally occurring variations in maternal behavior are associated with differences in estrogen-inducible oxytocin receptors in the medial preoptic area (MPOA) of the hypothalamus. We compared levels of ER alpha and ER beta mRNA in the MPOA of lactating High or Low LG mothers a...
متن کاملsiRNA silencing of estrogen receptor-α expression specifically in medial preoptic area neurons abolishes maternal care in female mice.
The medial preoptic area has been shown to be intricately involved in many behaviors, including locomotion, sexual behavior, maternal care, and aggression. The gene encoding estrogen receptor-α (ERα) protein is expressed in preoptic area neurons, and a very dense immunoreactive field of ERα is found in the preoptic region. ERα knockout animals show deficits in maternal care and sexual behavior ...
متن کاملMaternal Care Associated with Methylation of the Estrogen Receptor- 1b Promoter and Estrogen Receptor- Expression in the Medial Preoptic Area of Female Offspring
Variations in maternal behavior are associated with differences in estrogen receptor (ER)expression in the medial preoptic area (MPOA) and are transmitted across generations such that, as adults, the female offspring of mothers that exhibit increased pup licking/grooming (LG) over the first week postpartum (i.e. high LG mothers) show increased ER expression in the MPOA and are themselves high L...
متن کاملProlactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior.
Pregnancy hormones, such as prolactin, sensitize neural circuits controlling parental interactions to induce timely activation of maternal behaviors immediately after parturition. While the medial preoptic area (MPOA) is known to be critical for maternal behavior, the specific role of prolactin in this brain region has remained elusive. Here, we evaluated the role of prolactin action in the MPO...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2021
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2021.109204